Tissue Engineering and Bioreactors

Tissue Engineering is a discipline integrating biology with engineering to create tissues or cellular products outside the body or to make use of gained knowledge to better manage the repair of tissues within the body.


During last decades significant progresses have been carried out in the field of tissue engineering, joining the skills of different specialists (i.e. engineers, surgeons, biologists). In particular, biomedical engineers are involved in the design and implementation of bioreactor systems for cell culture protocols. These devices play an important role in applying the proper biomechanical stimuli, over a 3D tissue construct, to address the desired cell phenotype.

The activities within the IBNE are oriented towards the development of bioreactor systems for osteogenic, cartilaginous, tenogenic and angiogenic differentiation, and the use of different 3D scaffold in the form of hydrogel or aerogel.

Our most recent work has been on the design of a standalone bioreactor system to deliver compressive load under perfusion flow to hBMSC-seeded 3D chitosan-graphene templates. See Link


Moreover, an international collaboration with the University of Bologna contribute to involve the IBNE in really innovative projects, such as the development of: in vitro tumor models for pre-clinical research protocols; devices for the non-destructive/real-time/in-line analysis, of 3D tissue construct based, on optical absorption or electrical impedance tomography. See also Link


Prof. Olafur Sigurjonsson - oes@ru.is

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