Available masters and doctoral projects

An overview of opportunities for students to work with scientists at Reykjavik University on research projects. Please contact the person listed within each project for further information.

Undergraduate level projects are on the Icelandic portion of RU's website: Available undergraduate level projects

  • Bone gain/loss analysis in 2D and 3D dimensions after total hip replacement

Bone gain/loss analysis in 2D and 3D dimensions after Total Hip Replacement (THR)

MSc level project, School of Science and Engineering

Abstract

Total Hip Replacement (THR) is one of the most utilized orthopedical surgical procedures. An app  based tool to assess bone quality pre and post surgery may help clinicians in decision making and in monitoring bone quality and bone-prosthesis integration in THR patients. In order to be clinically and ethically compatible such tool should be based on 2D images (low radiation dose)  of standardized regions of interest. In this project, 3D data of Bone Mineral Density (BMD) pre vs. 1- year post operation are utilized to develop a 2D approach for the assessment of gain/loss, based on standard CT-Scans.

Description

The assessment methods are based on data from CT-scans acquired from patients undergoing THA at 3 different times: before operation, post 24 hours and 1 year post- operation.  The pre and post data are processed, reconstructed in 3D, registered and compared; in this way the 3D evaluation of gain and loss after 1 year from THA is achieved as shown in Fig 1.  Based on this 3D approach we aim to develop a 2D  procedure, selecting specific axial and coronal slices from a dataset, that can possibly enable provide similar information.  For this propose, different analysis methods are applied to the selected slices using MATLAB obtaining a bi-dimensional description of the bone (density distribution, number of pixels per Hounsfield Unit) that can be used to evaluate bone quality (Fig 1.b: model fitting on the distribution and assessment of the model's parameters) or to extract the same information as the 3D approach, such as BMD gain/loss (Fig 1.c: comparison of Average HU profile).

Goal

The ultimate aim of the project is the creation of an app, that would be an affordable and easy tool for clinicians to evaluate bone quality and increase both decision making pre operative and post operative rehabilitation strategies.

Funded?

No

Other

The project is based on a synergic collaboration between Landspítali – University Hospital of Iceland and the Reykjavík University.

Contact

paolo@ru.is and magnuskg@ru.is